![]() In ESCAPE, researchers were on average two hours faster in opening the blocked blood vessels than in previously reported trials.ĮSCAPE is the second ET trial that demonstrates the efficacy of the treatment and the first trial to demonstrate reduced mortality. The ESCAPE team says the success of the trial can be credited to very fast treatment and the use of brain and blood vessel imaging. The clot is then removed by a retrievable stent and pulled out, restoring blood flow to the brain.Įndovascular treatments were first developed in the 1990s, but ET has only recently been technically possible. ![]() This is done under image-guided care using an X-ray. In the ESCAPE trial, 316 patients who fit the criteria for ET and arrived for treatment within 12 hours of their stroke were randomized to standard medical care (which included the clot-busting drug tPA where appropriate) or standard medical care plus ET.ĮT is performed by inserting a thin tube into the artery in the groin, through the body, and into the brain vessels to the clot. ![]() Known as a ‘clot buster’, the drug dissolves the blood clot. and European guidelines is to administer a drug called tPA when appropriate. Currently, the international standard of care based on Canadian, U.S. Ischemic stroke is caused by a sudden blockage of an artery to the brain that deprives the brain of critical nutrients, such as glucose and oxygen. The clinical trial, known as ESCAPE (Endovascular treatment for Small Core and Anterior circulation Proximal occlusion with Emphasis on minimizing CT to recanalization times), shows there is a marked reduction in both disability and death among patients who receive ET for acute ischemic stroke. The overall mortality rate was reduced from two in 10 patients for standard treatment of care to one in 10 patients – a 50 per cent reduction with ET. In many cases, instead of suffering major neurological disability, patients went home to resume their lives. Overall, positive outcomes for patients increased from 30 per cent to 55 per cent. 11 online edition of the New England Journal of Medicine (NEJM). The results of this study were published in the Feb. The study, led by researchers at the University of Calgary’s Hotchkiss Brain Institute (HBI), shows a dramatic improvement in outcomes and a reduction in deaths from stroke. Temple University Hospital | Philadelphia, Penn.Ĭanadian researchers have completed an international randomized controlled trial showing that a clot retrieval procedure, known as endovascular treatment (ET), can dramatically improve patient outcomes after an acute ischemic stroke.Keimyung University (Dongsan Medical Centre) | Daegu, South Korea.Samsung Medical Centre | Seoul, South Korea.Yonsei University (Severance Hospital) | Seoul, South Korea.Abington Memorial Hospital | Abington, Penn.McGill University (MNI) | Montreal, Que.London Health Sciences Centre | London, Ont.Sunnybrook Health Sciences Centre | Toronto, Ont.MUSC-Medical University of South Carolina | Charleston, S.C.CHUM-Hospital Notre-Dame | Montreal, Que.Chattanooga Center for Neurologic Research | Chattanooga, Tenn.University of Alberta Hospital | Edmonton, Alta.Toronto Western Hospital | Toronto, Ont.UPMC Medical Centre | Pittsburgh, Penn.Colorado Neurological Institute | Denver, Colo.Royal University Hospital | Saskatoon, Sask.Foothills Medical Centre | Calgary, Alta. ![]() Canada had 11 participating hospitals and enrolled two-thirds of the patients. The study included 22 sites worldwide and patients in the U.S., U.K., Ireland and South Korea. ![]()
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